Synthetic Strategies Toward the Decalin Motif of Maklamicin and Related Spirotetronates.
نویسندگان
چکیده
Herein we describe a scalable approach to the decalin moiety of maklamicin. Key to the synthesis is an intramolecular Diels-Alder (IMDA) reaction that proceeds via an endo-axial transition state to generate the desired stereochemistry. We explored the diastereoselectivity of the IMDA reaction as a function of both chiral catalysis and acyclic precursor stereochemistry.
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ورودعنوان ژورنال:
- Organic chemistry frontiers : an international journal of organic chemistry
دوره 2 4 شماره
صفحات -
تاریخ انتشار 2015